Cisplatin loaded PMMA: mechanical properties, surface analysis and effects on Saos-2 cell culture

OEZBEN H., Eralp L., Baysal G., Cort A., Sarkalkan N., Ozben T.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, cilt.47, sa.3, ss.184-192, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3944/aott.2013.2828
  • Dergi Adı: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.184-192
  • Anahtar Kelimeler: Bone cement, cisplatin, osteosarcoma, BONE-CEMENT, ACRYLIC CEMENT, IN-VITRO, LOCAL CHEMOTHERAPY, METHOTREXATE, POLYMETHYLMETHACRYLATE, METASTASIS, TUMOR, LINES
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective: Despite wide resection and systemic chemotherapy, bone tumors may present with local recurrences, metastases and pathological fractures. Application of bone cement containing antineoplastic drug to fill the defect after resection of metastatic lesions and to support implants has been suggested to prevent local tumor growth and implant failures. In this study, we aimed to demonstrate the effects of the addition of cisplatin which is a widely used antineoplastic drug for osteosarcoma, on the mechanical properties of bone cement, and to evaluate the cytotoxic effects of eluted cisplatin on Saos-2 cell culture.