Cisplatin loaded PMMA: mechanical properties, surface analysis and effects on Saos-2 cell culture

OEZBEN H., Eralp L., Baysal G., Cort A., Sarkalkan N., Ozben T.

ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, vol.47, no.3, pp.184-192, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.3944/aott.2013.2828
  • Journal Name: ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.184-192
  • Keywords: Bone cement, cisplatin, osteosarcoma, BONE-CEMENT, ACRYLIC CEMENT, IN-VITRO, LOCAL CHEMOTHERAPY, METHOTREXATE, POLYMETHYLMETHACRYLATE, METASTASIS, TUMOR, LINES
  • Akdeniz University Affiliated: Yes

Abstract

Objective: Despite wide resection and systemic chemotherapy, bone tumors may present with local recurrences, metastases and pathological fractures. Application of bone cement containing antineoplastic drug to fill the defect after resection of metastatic lesions and to support implants has been suggested to prevent local tumor growth and implant failures. In this study, we aimed to demonstrate the effects of the addition of cisplatin which is a widely used antineoplastic drug for osteosarcoma, on the mechanical properties of bone cement, and to evaluate the cytotoxic effects of eluted cisplatin on Saos-2 cell culture.