The role of High Mobility Group Box 1 (HMGB1) in colorectal cancer

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Suren D., Yildirim M., Demirpence O., KAYA V., Alikanoglu A. S., Bulbuller N., ...Daha Fazla

MEDICAL SCIENCE MONITOR, cilt.20, ss.530-537, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2014
  • Doi Numarası: 10.12659/msm.890531
  • Dergi Adı: MEDICAL SCIENCE MONITOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.530-537
  • Anahtar Kelimeler: Colorectal Neoplasms - pathology, HMGB1 Protein - diagnostic use, Prognosis, SQUAMOUS-CELL CARCINOMA, COLON-CANCER, CYCLOOXYGENASE-2 EXPRESSION, CLINICAL-SIGNIFICANCE, IN-VITRO, PROGRESSION, PROTEINS, PROGNOSIS, OVEREXPRESSION, APOPTOSIS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: HMGB1, the most important member of the high mobility group box protein family, is a nuclear protein with different functions in the cell; it has a role in cancer progression, angiogenesis, invasion, and metastasis development. We studied the expression of HMGB1 and whether it is a prognostic factor in colorectal carcinoma.