Hyperglycaemia-induced subcellular redistribution of GLUT1 glucose transporters in cultured human term placental trophoblast cells

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Hahn T., Hahn D., Blaschitz A., Korgun E. T., Desoye G., Dohr G.

DIABETOLOGIA, vol.43, no.2, pp.173-180, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 2
  • Publication Date: 2000
  • Doi Number: 10.1007/s001250050026
  • Journal Name: DIABETOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.173-180
  • Keywords: GLUT1, translocation, glucose, transport, hyperglycaemia, diabetes, trophoblast, placenta, pregnancy, electron microscopy, INSULIN-INDUCED TRANSLOCATION, 3T3-L1 ADIPOCYTES, PLASMA-MEMBRANE, SKELETAL-MUSCLE, ADIPOSE-CELLS, IN-VITRO, RAT, LOCALIZATION, ISOFORMS, TRAFFICKING
  • Open Archive Collection: AVESIS Open Access Collection
  • Akdeniz University Affiliated: Yes

Abstract

Aims/hypothesis. We have recently shown that hyperglycaemia down-regulates the GLUT1 glucose transport system of term placental trophoblast. The reduction in GLUT1 protein alone was, however, not sufficient to explain the decrease in net glucose uptake, suggesting additional mechanisms. Therefore, we hypothesised that hyperglycaemia in vitro leads to a GLUT1 translocation from the trophoblast surface to intracellular sites.