Cytotoxicity, Apoptotic, Antioxidant and Antimicrobial Activity of Dictyota dichotoma (Hudson) J.V. Lamouroux 1809 Collected from Antalya Coast, Turkiye

Sevki Arslan A., Abdelsalam A. H., Kızıldoğan A. K., Otur Ç., Konuş M., Çetin D., ...Daha Fazla

Biology Bulletin, cilt.52, sa.1, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 1
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1134/s1062359024608814
  • Dergi Adı: Biology Bulletin
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, Artic & Antarctic Regions, BIOSIS, CAB Abstracts, Veterinary Science Database
  • Anahtar Kelimeler: antioxidant activity, apoptosis antimicrobial potential, cytotoxic activity, Dictyota dichotoma, gene expression
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Abstract: Current study was purposed to reveal the cytotoxic, apoptotic, antimicrobial and antioxidant potentials of oil extracted from Dictyota dichotoma (Hudson) J.V. Lamouroux 1809 collected from Antalya coast of Turkiye. Dictyota dichotoma oil showed better cytotoxic activity towards two different adenocarcinoma cell lines (Caco-2 (8.83 μg/mL) and LnCap (10.86 μg/mL)) compared to HEK293 cells (non-cancerous). Annexin V/PI staining and qPCR studies revealed that oil caused induction of apoptosis. Dictyota dichotoma oil inhibited the growth of Aspergillus niger ATCC 16404 and Enterococcus faecalis ATCC 29212. Nevertheless, the lower antioxidant activity of Dictyota dichotoma oil was determined compared with trolox standard for both DPPH and ABTS assays (4.8 fold less). In conclusion, Dictyota dichotoma oil has a promising potential in medical usage.