Serum ferritin, vitamin B-12, folate, and zinc levels in children infected with Helicobacter pylori

Akcam M., Ozdem S., Yilmaz A., Gultekin M., Artan R.

DIGESTIVE DISEASES AND SCIENCES, cilt.52, sa.2, ss.405-410, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s10620-006-9422-8
  • Dergi Adı: DIGESTIVE DISEASES AND SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.405-410
  • Anahtar Kelimeler: Helicobacter pylori, child, vitamin B-12, folate, zinc, micronutrient, IRON-DEFICIENCY ANEMIA, GASTRIC-ACID-SECRETION, ABSORPTION, COBALAMIN, DISEASE, PROTEIN, ADULTS, JUICE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

We sought to explore the relationship between Helicobacter pylori infection and serum ferritin, vitamin B-12, folate, and zinc status among children. Fifty patients aged 5-18 years who underwent upper gastrointestinal endoscopy because of dyspeptic symptoms, were studied, prospectively. Patients were grouped as H. pylori positive (group 1, n=32) or H. pylori negative (group 2, n=18) by histopathologic examination and rapid urease test. Fasting serum ferritin, vitamin B-12, folate, and zinc levels of patients were measured. Both groups were indifferent according to age, gender, height standard deviation score (H-SDS), and weight standard deviation score (W-SDS). Serum ferritin levels were 33 +/- 26 and 50 +/- 46 ng/mL (P=.098), vitamin B-12 levels were 303 +/- 135 and 393 +/- 166 pg/mL (P=.042), folate levels were 9.64 +/- 3.2 and 9.61 +/- 2.8 ng/mL (P=.979), and zinc levels were 95 +/- 48 and 87 +/- 31 mu g/dL (P=.538), in groups 1 and 2, respectively. Ferritin levels of 14 (43.8%) patients in group 1 and 6 (33.3%) patients in group 2 were below the normal range (P=.470). Serum vitamin B-12 levels of 9 children (28%) in group 1 and 2 children (11%) in group 2 were below the normal range (P=.287). The findings of the present study suggest that H. pylori infection has a negative effect on serum ferritin and vitamin B-12 levels in children. This negative effect on vitamin B-12 levels is rather marked in contrast to that on ferritin levels. H. pylori infection has no significant effect on serum folate or zinc levels among children.