Use of a Y-Tube Conduit After Facial Nerve Injury Reduces Collateral Axonal Branching at the Lesion Site But Neither Reduces Polyinnervation of Motor Endplates Nor Improves Functional Recovery

HİZAY, ARZU; ÖZSOY, UMUT; DEMİREL, BAHADIR; ÖZSOY, ÖZLEM; Angelova, Srebrina; Ankerne, Janina; Sarikcioglu, SÜREYYA; Dunlop, Sarah; Angelov, Doychin; SARIKCIOĞLU, LEVENT

doi:10.1227/neu.0b013e318249f16f

Use of a Y-Tube Conduit After Facial Nerve Injury Reduces Collateral Axonal Branching at the Lesion Site But Neither Reduces Polyinnervation of Motor Endplates Nor Improves Functional Recovery

HİZAY A., ÖZSOY U., DEMİREL B. M., ÖZSOY Ö., Angelova S. K., Ankerne J., ...Daha Fazla

NEUROSURGERY, cilt.70, sa.6, ss.1544-1556, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 70 Sayı: 6
Basım Tarihi: 2012
Doi Numarası: 10.1227/neu.0b013e318249f16f
Dergi Adı: NEUROSURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1544-1556
Anahtar Kelimeler: Entubulation, Facial nerve, Functional recovery, Motor neuron, Nerve repair, MANUAL STIMULATION, SELECTIVE REINNERVATION, SCIATIC-NERVE, RECONSTRUCTIVE SURGERY, MUSCLE REINNERVATION, TISSUE-SPECIFICITY, VIBRISSAL MOVEMENT, SKELETAL-MUSCLE, FEMORAL NERVE, SCHWANN-CELLS
Akdeniz Üniversitesi Adresli: Evet

Özet

BACKGROUND: Despite increased understanding of peripheral nerve regeneration, functional recovery after surgical repair remains disappointing. A major contributing factor is the extensive collateral branching at the lesion site, which leads to inaccurate axonal navigation and aberrant reinnervation of targets.