Epimorphin expression in a rat model of pulmonary hypoplasia associated with congenital diaphragmatic hernia

Akpinar I., Korgun D., Cetin A., YEŞİLKAYA A., KARAGÜZEL G., Boneval C., ...Daha Fazla

PEDIATRIC SURGERY INTERNATIONAL, cilt.30, sa.10, ss.1037-1043, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 10
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s00383-014-3579-6
  • Dergi Adı: PEDIATRIC SURGERY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1037-1043
  • Anahtar Kelimeler: Epimorphin, Congenital diaphragmatic hernia, Pulmonary hypoplasia, Nitrofen, LUNG HYPOPLASIA, NITROFEN, GROWTH
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The pathogenesis of pulmonary hypoplasia associated with congenital diaphragmatic hernia (CDH) remains unclear. Interactions between the epithelium and surrounding mesenchyme play an important role in normal lung morphogenesis. Epimorphin, a stromal protein, plays a role in epithelial morphogenesis and lung branching, both of which are involved in pulmonary hypoplasia. In this study, we aimed to examine the relationship between epimorphin and pulmonary hypoplasia associated with CDH in an animal model.