Akademik Veri Yönetim Sistemi
Journal of Paediatrics and Child Health, cilt.58, sa.3, ss.459-462, 2022 (SCI-Expanded)
Aim: This study aimed to investigate parenchymal changes in the liver in paediatric patients with cystic fibrosis (CF) and to analyse diagnostic performance of two-dimensional shear wave elastography (2D-SWE) for the detection of hepatic involvement. Methods: Patients with CF treated and followed at our centre were evaluated prospectively. All patients underwent liver tissue stiffness (TS) measurements by 2D-SWE, in addition to routine clinical assessments, laboratory work-up and abdominal ultrasound imaging. Data from patients with CF were compared with healthy control subjects. Results: This study included 39 patients with CF and 37 healthy controls. Patients had a mean body weight of 29.9 (16.6–55) kg, mean age of 9 (5–17) years, mean height of 130 (107–172) cm and a mean body mass index of 16.1 (12.8–21.4) kg/m2. Average SWE values of the liver were 1.02 (0.70–1.60) m/s in patients with CF (n = 39) and 0.89 (0.60–1.35) m/s in healthy controls (n = 37). Cystic fibrosis patients had significantly increased tissue stifness by liver elastography compared to controls (P = 0.005). Conclusion: Parenchymal liver changes may occur early in cystic fibrosis, which cannot be detected by conventional ultrasonography but may be demonstrated by 2D-SWE. Based on this cross-sectional study, 2D-SWE may be a promising, simple and non-invasive modality for objective monitoring of patients with cystic fibrosis who require lifelong follow-up, by providing numerical data for tissue stiffness early in the disease.