Placental Growth Factor and Endothelial Cell-Specific Molecule 1 Levels in Discordant and Concordant Twins and Their Effects on Fetal Growth

Simsek G. K., Arayici S., Okur N., Buyuktiryaki M., Canpolat F. E., Oguz S. S.

FETAL AND PEDIATRIC PATHOLOGY, cilt.38, sa.2, ss.146-152, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/15513815.2018.1561773
  • Dergi Adı: FETAL AND PEDIATRIC PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.146-152
  • Anahtar Kelimeler: PGF, ESM-1, discordance, twin, fetal growth, FACTOR-I, SERUM
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Objective: We explored whether fetal twin growth was related to the levels of placental growth factor (PGF) and endothelial cell-specific molecule 1 (ESM-1) and sought correlations between cord blood PGF and ESM1 levels and birth weight discordance. Methods: This was a prospective study. We evaluated 79 pairs of twins, thus 158 infants. Twenty-nine (37%) twins were naturally conceived; the remaining 50 (63%) resulted from assisted reproduction. Results: Nine (11%) sets of twins were monochorionic. Eighteen of the 79 twin sets (22%) were discordant. We found a positive correlation between PGF and ESM-1 levels (r=0.51, p=0.001) and between discordance and PGF level (r=0.430, p=0.001). Conclusion: The growth discordance may not be attributable to the different PGF levels, but the difference in PGF level may be a consequence.