Protective effects of ginkgo biloba extract on ligature-induced periodontitis in rats

Sezer U., Kara M. I., Erciyas K., Ozdemir H., ÜSTÜN K., ÖZER H., ...Daha Fazla

ACTA ODONTOLOGICA SCANDINAVICA, cilt.71, sa.1, ss.38-44, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/00016357.2011.650195
  • Dergi Adı: ACTA ODONTOLOGICA SCANDINAVICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.38-44
  • Anahtar Kelimeler: antioxidant, experimental periodontitis, ginkgo biloba extract, host modulation therapy, ALVEOLAR BONE LOSS, REACTIVE OXYGEN, FREE-RADICALS, OXIDATIVE STRESS, HUMAN-DISEASE, INFLAMMATION, ANTIOXIDANTS, MODEL, DESTRUCTION, SUPEROXIDE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Objective. The aim of this study was to test the hypothesis that the systemic administration of extract of Ginkgo biloba (EGb) would prevent excessive tissue destruction in ligature-induced periodontitis in a rat model. Materials and methods. Thirty-two male Wistar albino rats were used in the current study. The rats were randomly divided into four groups of eight rats each: (1) non-ligated treatment (NL) group, (2) ligature-only (LO) group, (3) ligature plus GB28 (28 mg/kg, daily for 11 days) group and (4) ligature plus GB56 (56 mg/kg, daily for 11 days) group. Results. Measurement of alveolar bone loss in the mandibular molar tooth revealed significantly lower bone loss values in the LO group compared to groups NL, GB28 and GB56 (p < 0.05). Conclusion. The present results are the first data which suggests that host response in periodontitis can be modified by EGb administration. EGb minimized progression of periodontal disease.