Research Information System
ACTA NEUROLOGICA TAIWANICA, no.32, pp.9-15, 2023 (SCI-Expanded)
Abstract
Objective: To evaluate the effect of using acetylsalicylic acid (aspirin) together with lansoprazole in the
secondary prevention of ischemic stroke.
Materials and methods: 199 patients with a diagnosis of ischemic stroke and transient ischemic attack
(TIA) using 100 mg of aspirin regularly was included in the study. All patients were evaluated for
the presence of aspirin resistance before starting the study. 57 patients with aspirin resistance were
excluded from the study. The remaining 142 patients were divided into two groups: the 1st group
consisted of those with stomach discomfort and the 2nd group consisted of those without stomach
discomfort. Patients in group 1 were given 30 mg of lansoprazole taken before breakfast in addition
to aspirin therapy. All patients were re-evaluated for the presence of aspirin resistance at a one-month
follow-up. The antiaggregant activity was evaluated by the impedance aggregometry method in both
groups.
Results: Of 142 patients, 75 were in group 1, and 67 were in group 2. There was no difference between
the two groups in terms of age and gender distribution of vascular risk factors. There was no
statistically significant difference between the two groups in terms of aspirin efficacy. The dose of
aspirin was increased in patients with aspirin resistance (AR).
Conclusion: The combination of 30 mg lansoprazole and 100 mg aspirin does not cause a decrease in
antiaggregant activity in the early period, but chronic use was not evaluated in this study. Patients
with AR may benefit from an increase in the dose of aspirin.
Keywords: Aspirin, proton pump inhibitors, aspirin resistance, ischemic stroke, transient global amnesia