Maternal Epilepsy and Umbilical Cord Blood Oxidative Stress Level
FETAL AND PEDIATRIC PATHOLOGY, cilt.41, sa.5, ss.731-740, 2022 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 41 Sayı: 5
- Basım Tarihi: 2022
- Doi Numarası: 10.1080/15513815.2021.1957046
- Dergi Adı: FETAL AND PEDIATRIC PATHOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
- Sayfa Sayıları: ss.731-740
- Anahtar Kelimeler: Epilepsy, albumin, ischemia modified albumin, thiol-disulfide homeostasis, oxidative stress, THIOL/DISULPHIDE HOMEOSTASIS, WOMEN, PREGNANCY, COMPLICATIONS, SEIZURE, CELLS, ASSAY
- Akdeniz Üniversitesi Adresli: Evet
Özet
Introduction We investigated the effect of epilepsy on cord blood oxidative stress status. Material and Methods Thirty (n = 30) pregnant women with epilepsy and thirty (n = 30) healthy controls enrolled in this case control study. Albumin and IMA values and dynamic thiol/disulfide parameters were measured. Results Decreased native thiol and total thiol levels were found in the epilepsy group when compared to the control group (p: 0.001, p: 0.002). Higher IMA (p: 0.036) and lower albumin cord levels (P < 0.001) were measured in the epilepsy group with respect to the control group. Apgar scores at 1 and 5 miutes were lower in the epilepsy group (respectively; p = 0.012, p = 0.010). A negative correlation was found between IMA and cord pH value (r = 0.288 p = 0.034). Conclusion This study showed that epilepsy may alter thiol disulfide homeostasis and IMA levels.