Maternal Epilepsy and Umbilical Cord Blood Oxidative Stress Level

Yakut K., Ocal F. D., Sanhal C. Y., Ocal O., Oguz Y., EREL Ö., ...Daha Fazla

FETAL AND PEDIATRIC PATHOLOGY, cilt.41, sa.5, ss.731-740, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/15513815.2021.1957046
  • Dergi Adı: FETAL AND PEDIATRIC PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.731-740
  • Anahtar Kelimeler: Epilepsy, albumin, ischemia modified albumin, thiol-disulfide homeostasis, oxidative stress, THIOL/DISULPHIDE HOMEOSTASIS, WOMEN, PREGNANCY, COMPLICATIONS, SEIZURE, CELLS, ASSAY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction We investigated the effect of epilepsy on cord blood oxidative stress status. Material and Methods Thirty (n = 30) pregnant women with epilepsy and thirty (n = 30) healthy controls enrolled in this case control study. Albumin and IMA values and dynamic thiol/disulfide parameters were measured. Results Decreased native thiol and total thiol levels were found in the epilepsy group when compared to the control group (p: 0.001, p: 0.002). Higher IMA (p: 0.036) and lower albumin cord levels (P < 0.001) were measured in the epilepsy group with respect to the control group. Apgar scores at 1 and 5 miutes were lower in the epilepsy group (respectively; p = 0.012, p = 0.010). A negative correlation was found between IMA and cord pH value (r = 0.288 p = 0.034). Conclusion This study showed that epilepsy may alter thiol disulfide homeostasis and IMA levels.