The efficacy of intravenous immunoglobulin on lipopolysaccharide-induced fetal brain inflammation in preterm rats
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, vol.209, no.4, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 209 Issue: 4
- Publication Date: 2013
- Doi Number: 10.1016/j.ajog.2013.06.027
- Journal Name: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Keywords: inflammation, interleukin-1 beta (IL-1 beta), intravenous immunoglobulin (IVIG), lipopolysaccharide, NECROSIS-FACTOR-ALPHA, WHITE-MATTER INJURY, INTERLEUKIN-1 RECEPTOR ANTAGONIST, INTRAUTERINE INFLAMMATION, EXPERIMENTAL-MODEL, CEREBRAL-PALSY, AMNIOTIC-FLUID, MATERNAL INFECTION, HYPOXIC ISCHEMIA, TNF-ALPHA
- Akdeniz University Affiliated: Yes
Abstract
OBJECTIVE: Interleukin-1 is accepted as one of the major cytokines; it is involved in inflammatory processes and systemic fetal inflammatory response that is triggered by maternal lipopolysaccharide (LPS) injection. Because it is an antiinflammatory agent, we investigated (in the brain damage of rat pups) the role of intravenous immunoglobulin (IVIG) in decreasing interleukin-1 beta (IL-1 beta) expression and caspase 3 activity that was induced by maternal LPS administration.