Specific interleukin-1 gene polymorphisms in Turkish patients with Behcet's disease

Coskun M., bacanli a., Sallakci N., Alpsoy E., Yavuzer U., Yegin O.

EXPERIMENTAL DERMATOLOGY, cilt.14, sa.2, ss.124-129, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.0906-6705.2005.00253.x
  • Dergi Adı: EXPERIMENTAL DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.124-129
  • Anahtar Kelimeler: Behcet's disease, gene polymorphisms, interleukin-1 alpha, interleukin-1 beta, interleukin-1 receptor antagonist genes, RECEPTOR ANTAGONIST GENE, SYSTEMIC-LUPUS-ERYTHEMATOSUS, INFLAMMATORY-BOWEL-DISEASE, NECROSIS-FACTOR-ALPHA, CLUSTER POLYMORPHISMS, RHEUMATOID-ARTHRITIS, PLASMA-LEVELS, ASSOCIATION, SEVERITY, ALLELE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Genetic factors that predispose individuals to Behcet's disease (BD) are considered to play important roles in the development of the disease. The pro-inflammatory cytokine interleukin-1 (IL-1) has been implicated in the pathogenesis of BD. Our aim was to determine a possible association of specific polymorphisms of IL-1alpha, IL-1beta, and IL-1 receptor antagonist genes with susceptibility for BD. We genotyped 72 patients with BD and 163 healthy controls for IL-1alpha-889, IL-1beta-511, and +3953 (nt5887) single-nucleotide polymorphisms besides IL-1 receptor antagonist variable number of tandem repeat polymorphism (for five different alleles). Comparison of the IL-1beta+3953 T allele and TT genotype frequencies showed a significant difference between patients with BD and controls (54.2 vs. 40.5%, OR = 1.74, P = 0.024, and 40.3 vs. 19.6%, OR = 2.76, P = 0.009, respectively). However, no difference was observed in the genotype or allele frequencies of IL-1alpha-889, IL-1beta-511, and IL-1 receptor antagonist between the patients with BD and the controls. Our results indicate that susceptibility to BD is increased in individuals carrying the IL-1beta+3953 T allele and TT genotype.