Evaluation of Aspergillus Lateral-Flow Test in Serum Samples of Pediatric Patients

FELEK R., Erman-Daloglu A., ÖZHAK B., Ogunc D., ÖNGÜT G., Gunseren F., ...More

CLINICAL LABORATORY, vol.67, no.4, pp.974-980, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.7754/clin.lab.2020.200746
  • Journal Name: CLINICAL LABORATORY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.974-980
  • Keywords: invasive aspergillosis, Aspergillus lateral flow device test, hematologic malignancy, BETA-D-GLUCAN, INVASIVE ASPERGILLOSIS, DIAGNOSIS, GALACTOMANNAN, DEVICE, PERFORMANCE, ASSAY, PCR
  • Akdeniz University Affiliated: Yes

Abstract

Background: Diagnosis of invasive aspergillosis (IA) in patients with hematologic malignancies and under the risk of IA may be uncertain or may delay because of nonspecific clinical presentation of the patients and difficult application techniques of conventional methods. Early diagnosis can provide initial antifungal therapy and prevent high mortality. In this study, we investigated the performance of an Aspergillus lateral-flow device (LFD) test (OLM Diagnostics, Newcastle upon Tyne, United Kingdom) for the diagnosis of IA in pediatric febrile neutropenic patients with hematologic malignancies.