Effects of statin use on total oxidant and antoxidant capacity and ceruloplasmin activity

Buyukhatipoglu H., Sezen Y., Yildiz A., Guntekin U., Bas M., Polat M., ...More

CLINICAL AND INVESTIGATIVE MEDICINE, vol.33, no.5, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 5
  • Publication Date: 2010
  • Journal Name: CLINICAL AND INVESTIGATIVE MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Akdeniz University Affiliated: No

Abstract

Purpose: Oxidative damage plays an important role in atherosclerosis development. Statin drugs have anti-oxidant properties, but the clinical value of their antioxidant properties remains unclear. In this study, our aims were: (1) to assess the anti-oxidant effects of statins in patients with coronary artery disease (CAD) using a newly developed valid measure of total oxidant and anti-oxidant capacity; and (2) to identify whether statins influence ceruloplamin levels.