Atıf İçin Kopyala
TAŞATARGİL A., Tekcan M., Celik-Ozenci C., Gungor N. E., Dalkiran B.
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, cilt.10, sa.3, ss.127-137, 2009 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
10
Sayı:
3
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Basım Tarihi:
2009
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Doi Numarası:
10.1177/1470320309343655
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Dergi Adı:
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.127-137
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Anahtar Kelimeler:
aldosterone, aorta, endothelial dysfunction, PARP, ADP-RIBOSE POLYMERASE, OXIDATIVE STRESS, POTASSIUM SECRETION, HYPERTENSIVE-RATS, REACTIVE OXYGEN, GENE DISRUPTION, INJURY, INHIBITION, SYSTEM, LIPOPOLYSACCHARIDE
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Akdeniz Üniversitesi Adresli:
Evet
Özet
Introduction. The aim of this study was to investigate whether activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) contributes to the development of aldosterone-induced endothelial dysfunction and treatment with the potent PARP inhibitor 1,5-isoquinolinediol (3 mg/kg/day, i.p.) could prevent endothelial dysfunction caused by aldosterone.