Aldosterone-induced endothelial dysfunction of rat aorta: role of poly(ADP-ribose) activation
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, vol.10, no.3, pp.127-137, 2009 (SCI-Expanded)
- Publication Type: Article / Article
- Volume: 10 Issue: 3
- Publication Date: 2009
- Doi Number: 10.1177/1470320309343655
- Journal Name: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.127-137
- Keywords: aldosterone, aorta, endothelial dysfunction, PARP, ADP-RIBOSE POLYMERASE, OXIDATIVE STRESS, POTASSIUM SECRETION, HYPERTENSIVE-RATS, REACTIVE OXYGEN, GENE DISRUPTION, INJURY, INHIBITION, SYSTEM, LIPOPOLYSACCHARIDE
- Akdeniz University Affiliated: Yes
Abstract
Introduction. The aim of this study was to investigate whether activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) contributes to the development of aldosterone-induced endothelial dysfunction and treatment with the potent PARP inhibitor 1,5-isoquinolinediol (3 mg/kg/day, i.p.) could prevent endothelial dysfunction caused by aldosterone.