Copy For Citation
TAŞATARGİL A., Tekcan M., Celik-Ozenci C., Gungor N. E., Dalkiran B.
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, vol.10, no.3, pp.127-137, 2009 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
10
Issue:
3
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Publication Date:
2009
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Doi Number:
10.1177/1470320309343655
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Journal Name:
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.127-137
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Keywords:
aldosterone, aorta, endothelial dysfunction, PARP, ADP-RIBOSE POLYMERASE, OXIDATIVE STRESS, POTASSIUM SECRETION, HYPERTENSIVE-RATS, REACTIVE OXYGEN, GENE DISRUPTION, INJURY, INHIBITION, SYSTEM, LIPOPOLYSACCHARIDE
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Akdeniz University Affiliated:
Yes
Abstract
Introduction. The aim of this study was to investigate whether activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) contributes to the development of aldosterone-induced endothelial dysfunction and treatment with the potent PARP inhibitor 1,5-isoquinolinediol (3 mg/kg/day, i.p.) could prevent endothelial dysfunction caused by aldosterone.