Expect the unexpected: fungemia caused by uncommon Candida species in a Turkish University Hospital

Alp S., GÜLMEZ KIVANÇ D., Kardas R. C., Karahan G., Tas Z., Gursoy G., ...Daha Fazla

European Journal of Clinical Microbiology and Infectious Diseases, cilt.40, sa.7, ss.1539-1545, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 7
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s10096-020-04147-5
  • Dergi Adı: European Journal of Clinical Microbiology and Infectious Diseases
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, CAB Abstracts, EMBASE, Environment Index, MEDLINE, Public Affairs Index, Veterinary Science Database
  • Sayfa Sayıları: ss.1539-1545
  • Anahtar Kelimeler: Antifungal susceptibility, Antifungal treatment, Breakthrough fungemia, Epidemiological cut-off value, Fungemia, Uncommon Candida species
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Fungemia caused by uncommon Candida species (UCS) (other than C.albicans, C.glabrata, C.parapsilosis, C.tropicalis, C.krusei) is a rare but emerging threat with their potential to exhibit reduced susceptibility or resistance to antifungal agents. We identified 25 patients with UCS fungemia (9 C.kefyr, 8 C.lusitaniae, 4 C.dubliniensis, 2 C.guilliermondii, 1 C.pelliculosa, 1 C.rugosa) through January 2011 and August 2018. Echinocandins were the most common administered agents, followed by fluconazole. Overall mortality was 44%. Echinocandins and voriconazole showed sufficient activity against all tested isolates. High fluconazole MICs among C.guilliermondii, C.pelliculosa, and C.rugosa were determined. MIC value of C.pelliculosa was above the epidemiological cut-off proposed for fluconazole.