Agar/kappa-carrageenan/montmorillonite nanocomposite hydrogels for wound dressing applications

Polat T. G., DUMAN O., TUNÇ S.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol.164, pp.4591-4602, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 164
  • Publication Date: 2020
  • Doi Number: 10.1016/j.ijbiomac.2020.09.048
  • Journal Name: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, INSPEC, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.4591-4602
  • Keywords: Polysaccharide, Montmorillonite, Nanocomposite hydrogel, Antibacterial, Drug release, Wound dressing material, DRUG-RELEASE BEHAVIOR, HIGH-STRENGTH, POLYMER HYDROGELS, DUAL RELEASE, CHITOSAN, SUPERABSORBENT, DELIVERY, GELLAN, MONTMORILLONITE, COMPOSITES
  • Akdeniz University Affiliated: Yes

Abstract

In this study, agar/kappa-carrageenan/montmorillonite (MMT) hydrogels were prepared to examine their usability as wound dressing materials and to see the effect of MMT amount on some properties of agar/kappa-carrageenan hydrogel materials. Hydrogels were characterized by SEM-EDX, TEM and DSC analyses. By increasing the MMT content within hydrogel matrix from 0% to 5%, the decomposition temperature of the hydrogel material was increased from 256.6 degrees C to 262.1 degrees C. Swelling amount of hydrogels in d-glucose solution (2682%) was found to be much higher compared with other physiological solutions such as physiological saline solution (937%), synthetic urine solution (746%) and simulated wound fluid (563%). The release studies of analgesic lidocaine hydrochloride (LDC) and antibiotic chloramphenicol (CLP) drugs from hydrogel systems demonstrated that the release amount of LDC and CLP from hydrogels could be controlled by MMT amount within hydrogel matrix. The concentrations of drugs within hydrogel sample stored at 4 degrees C for 6 months did not exhibit a significant change. Hydrogel materials containing CLP exhibited good antibacterial activity against E. coli and S. aureus. Cytotoxicity test results indicated that hydrogels were biocompatible with MG-63 cells. The ultimate compressive stress of agar/kappa-carrageenan hydrogel with LDC and CLP and agar/kappa-carrageenan/MMT hydrogel including 5% MMT with LDC and CLP was measured as 38.30 kPa and 47.70 kPa, respectively. The experimental results revealed that prepared agar/kappa-carrageenan and agar/kappa-carrageenan/MMT hydrogels have great potential for wound care applications. (C) 2020 Elsevier B.V. All rights reserved.