Analysis of paraoxonase 1 (PON1) genetic polymorphisms and activities as risk factors for ischemic stroke in Turkish population
CELL BIOCHEMISTRY AND FUNCTION, cilt.27, sa.8, ss.558-567, 2009 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 8
- Basım Tarihi: 2009
- Doi Numarası: 10.1002/cbf.1607
- Dergi Adı: CELL BIOCHEMISTRY AND FUNCTION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.558-567
- Anahtar Kelimeler: genotype, paraoxonase, PON1, polymorphism, stroke, HUMAN-SERUM PARAOXONASE, DENSITY-LIPOPROTEIN OXIDATION, INTIMA-MEDIA THICKNESS, ARYLESTERASE, PROMOTER, PROTEIN, ASSOCIATION, CHOLESTEROL, HYDROLYSIS, PHENOTYPE
- Akdeniz Üniversitesi Adresli: Hayır
Özet
Background Paraoxonase 1 (PON1) is protective against the development of atherosclerosis. a risk factor for ischemic stroke. PON1 gene has one promoter region (-107T/C) and two coding region (192Q/R and 55L/M) polymorphisms that affect the levels and catalytic efficiency of the enzyme. respectively. In this study. we aimed to determine the importance of -107T/C. 192Q/R and 55L/M polymorphisms of PON1 gene and three PON1 activity (diazoxonase, paraoxonase, arylesterase) as risk factors for ischemic stroke