Thiopurine S-methyltransferase gene polymorphism in pemphigus vulgaris

Genc A., GÜNAŞTI S., TULİ A., ÇÜRÜK M. A., UZUN S.

POSTEPY DERMATOLOGII I ALERGOLOGII, cilt.29, sa.1, ss.25-29, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 1
  • Basım Tarihi: 2012
  • Dergi Adı: POSTEPY DERMATOLOGII I ALERGOLOGII
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.25-29
  • Anahtar Kelimeler: thiopurine S-methyltransferase, azathioprine, pemphigus vulgaris, pharmacogenetic, INFLAMMATORY-BOWEL-DISEASE, AZATHIOPRINE THERAPY, CROHNS-DISEASE, PHARMACOGENETICS, GENOTYPE, PHENOTYPE, TPMT, POPULATION, FREQUENCY, LEUKEMIA
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction: Thiopurine S-methyltransferase (TPMT) genotypes or phenotypes are important as a predictive factor for thiopurine-induced toxicity. Individuals who are TPMT deficient or have intermediate TPMT activity are at risk of developing myelosuppression and life-threatening leucopenia when treated with standard doses of thiopurines; thus, pretreatment identification of these individuals is very important.