Thiopurine S-methyltransferase gene polymorphism in pemphigus vulgaris
POSTEPY DERMATOLOGII I ALERGOLOGII, cilt.29, sa.1, ss.25-29, 2012 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 1
- Basım Tarihi: 2012
- Dergi Adı: POSTEPY DERMATOLOGII I ALERGOLOGII
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.25-29
- Anahtar Kelimeler: thiopurine S-methyltransferase, azathioprine, pemphigus vulgaris, pharmacogenetic, INFLAMMATORY-BOWEL-DISEASE, AZATHIOPRINE THERAPY, CROHNS-DISEASE, PHARMACOGENETICS, GENOTYPE, PHENOTYPE, TPMT, POPULATION, FREQUENCY, LEUKEMIA
- Akdeniz Üniversitesi Adresli: Evet
Özet
Introduction: Thiopurine S-methyltransferase (TPMT) genotypes or phenotypes are important as a predictive factor for thiopurine-induced toxicity. Individuals who are TPMT deficient or have intermediate TPMT activity are at risk of developing myelosuppression and life-threatening leucopenia when treated with standard doses of thiopurines; thus, pretreatment identification of these individuals is very important.