Expression of PTEN protein in patients with laryngeal squamous cell carcinoma

GÜNEY K., ÖZBİLİM G., DERİN A. T., ÇETİN S.

AURIS NASUS LARYNX, vol.34, no.4, pp.481-486, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 34 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1016/j.anl.2007.03.014
  • Journal Name: AURIS NASUS LARYNX
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.481-486
  • Keywords: PTEN, larynx, cancer, TUMOR-SUPPRESSOR GENE, PROGNOSTIC-SIGNIFICANCE, AERODIGESTIVE TRACT, GERMLINE MUTATIONS, COWDEN-DISEASE, PTEN/MMAC1, DELETION, CANCERS, BREAST, DIFFERENTIATION
  • Akdeniz University Affiliated: Yes

Abstract

Objective: PTEN (phosphatase and tensin homologue deleted on chromosome 10), also referred to as MMACI (mutated in multiple advanced cancers) gene was recently identified as a putative tumor suppressor in a variety of malignant tumors. PTEN expression has been investigated in some squamous cell carcinomas (SCC) of head and neck. However, there is only little knowledge about laryngeal malignancies. Therefore, we examined PTEN product protein immunohistochemically in 30 consecutive laryngeal specimens from patients with laryngeal SCC and compared the results according to the clinicopathologic characteristics of the patients.