Osteonecrosis of the jaw in a patient on raloxifene: A case report

Baur D. A., ALTAY M. A., Teich S., Oswald M. S., Quereshy F. A.

QUINTESSENCE INTERNATIONAL, cilt.46, sa.5, ss.423-428, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3290/j.qi.a32918
  • Dergi Adı: QUINTESSENCE INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.423-428
  • Anahtar Kelimeler: jaw, mandible, osteonecrosis, raloxifene, BISPHOSPHONATE-RELATED OSTEONECROSIS, ESTROGEN-RECEPTOR MODULATORS, DENTAL-ASSOCIATION COUNCIL, SURGEONS POSITION PAPER, POSTMENOPAUSAL WOMEN, AMERICAN ASSOCIATION, THERAPY, RECOMMENDATIONS, PREVENTION, SERMS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Osteonecrosis of jaws (ONJ) is a chronic disease characterized by necrotic bone from any number of causes. ONJ can also occur due to several systemic and local factors which compromise blood flow within the bone. Among anti-resorptive medications, a very low risk of ONJ development is associated with oral bisphosphonates used for the management of osteopenia, osteoporosis, and Paget's disease. Raloxifene is a nonsteroidal benzothiophene which is classified as a selective estrogen receptor modulator (SERM). It is commonly used for the prevention and the treatment of osteoporosis in postmenopausal women and was recently approved to reduce the risk of breast cancer. Raloxifene is regarded as a safe alternative in the management of osteoporosis in terms of ONJ development. This report presents a case of ONJ in a patient receiving raloxifene, who presented with existing comorbidities and a history of discontinued oral bisphosphonates use. The clinical report is followed by a discussion aimed to clarify how the general practitioner should consider similar cases.