Investigating the role of salivary Interleukin-40 levels in diagnosing periodontal diseases
Oral Diseases, vol.30, no.8, pp.5315-5325, 2024 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 30 Issue: 8
- Publication Date: 2024
- Doi Number: 10.1111/odi.14936
- Journal Name: Oral Diseases
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, MEDLINE, Veterinary Science Database
- Page Numbers: pp.5315-5325
- Keywords: gingivitis, Interleukin-1β, Interleukin-40, MMP-8, periodontitis, saliva
- Akdeniz University Affiliated: Yes
Abstract
Background: The present study aimed to analyze IL-40, IL-1β, and MMP-8 levels in periodontitis as well as gingivitis and periodontal health, and to explore potential correlations between these biomarkers and standard clinical parameters. Materials and methods: We collected saliva samples from 120 systemically healthy, non-smoking individuals aged between 18 and 63 years. These individuals were divided into three groups: healthy controls [S], gingivitis [G], and stage III grade B periodontitis [P]. IL-40, IL-1β, and MMP-8 levels in saliva samples were analyzed by ELISA. Results: We observed significantly elevated salivary IL-40 levels in the G group compared to the S group (p = 0.003). We found significantly higher salivary IL-1β levels in the P group compared to both the S and G groups (p = 0.000). Salivary MMP-8 levels were significantly higher in the P group than in the S group (p = 0.016). Conclusion: Our study suggests that IL-40 and IL-1β may serve as effective salivary biomarkers for diagnosing gingivitis, while MMP-8 and IL-1β may be effective for distinguishing periodontitis. Based on our study's findings, it can be stated that IL-40 may serve as a new and effective biomarker for distinguishing individuals with gingivitis from healthy ones.