Effect of exercise on blood pressure in rats with chronic NOS inhibition
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, cilt.87, sa.2, ss.134-140, 2002 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 87 Sayı: 2
- Basım Tarihi: 2002
- Doi Numarası: 10.1007/s00421-002-0602-8
- Dergi Adı: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.134-140
- Anahtar Kelimeler: exercise, blood pressure, hypertension, nitric oxide, nitric oxide synthase, NITRIC-OXIDE SYNTHASE, SPONTANEOUSLY HYPERTENSIVE RATS, ENDOTHELIAL DYSFUNCTION, CHRONIC BLOCKADE, HYPERTROPHY, CONTRIBUTE, PREVENTION, ARTERY, FLOW
- Akdeniz Üniversitesi Adresli: Evet
Özet
Regular training lowers blood pressure in hypertensive humans and other animals. We investigated the response to 4 weeks of treadmill exercise training in hypertensive male Wistar rats receiving the nitric oxide synthase inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME). The rats were on either a short- (4 weeks) or long-term (10 weeks) L-NAME treatment protocol and were subjected to running exercise that started concomitantly in the short-term group and in the 6th week in the long-term group. Four weeks of exercise training induced a fall in mean arterial pressure in both the short[mean (SEM) 137.6 (4.0) mmHg] and long-term hypertensive groups [161.4 (2.3) mmHg] compared to their sedentary hypertensive controls [160.4 (3.3) mmHg and 176.8 (8.9) mmHg, respectively]. Exercise also increased muscle nitric oxide synthase activity in both of the trained hypertensive groups. Muscle nitrite levels were higher in the exercising short-term hypertensive group compared to both the sedentary control and the sedentary hypertensive groups, and were not different between the sedentary and exercising long-term hypertensive groups. Increased wall thickness of the aortic and mesenteric vessels was observed in the hypertensive groups, but was prevented in the exercising long-term hypertensive group. In rat, exercise reduces the elevated blood pressure in L-NAME-induced hypertension via increasing nitric oxide synthase activity. Changes in vessel structure with exercise training may also be involved in the blood-pressure-lowering effects.