The association of serum prolidase activity with the presence and severity of coronary artery disease

Yildiz A., Demirbag R., Yilmaz R., Gur M., Altiparmak I. H., Akyol S., ...Daha Fazla

CORONARY ARTERY DISEASE, cilt.19, sa.5, ss.319-325, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/mca.0b013e32830042ba
  • Dergi Adı: CORONARY ARTERY DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.319-325
  • Anahtar Kelimeler: atherosclerosis, collagen turnover, extracellular matrix, oxidative stress, prolidase activity, TISSUE INHIBITOR, MATRIX METALLOPROTEINASE-3, EXTRACELLULAR-MATRIX, PLASMA, MATRIX-METALLOPROTEINASE-9, FIBROBLASTS, DEFICIENCY, EXPRESSION, TURNOVER, PLAQUES
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Objectives Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with carboxy-terminal proline or hydroxyproline and plays major role in Collagen turnover. Collagen is the essential content in atherosclerotic plaque playing a key role in the stability/instability of and progression of coronary artery disease (CAD). Consequently, in this study we sought to determine serum prolidase activity and markers of oxidative stress such as lipid hydroperoxide and total free sulfhydryl in CAD.