Adjunctive %0.8 Hyaluronic Acid in Non-Surgical Therapy

CED/NOF IADR ORAL HEALTH RESEARCH CONGRESS, Lisbon, Portekiz, 3 - 05 Eylül 2026, ss.157-160, (Özet Bildiri)

Objectives This study aimed to evaluate the clinical effects of 0.8% hyaluronic acid (HA) as an adjunct to

scaling and root planing (SRP) in patients with periodontitis, with outcomes stratified according to

baseline pocket depth.

Methods In this retrospective study, clinical records of 42 systemically healthy patients previously treated

with non-surgical periodontal therapy were analyzed. Patients were allocated into two groups according

to treatment received: SRP alone (control, n=20) and SRP with adjunctive HA application (test, n=22). All

patients underwent full-mouth supra- and subgingival debridement. In the test group, 0.8% HA gel was

applied subgingivally into periodontal pockets ≥5 mm immediately after SRP within the same session.

Clinical parameters, including probing depth (PD), clinical attachment level (CAL), plaque index (PI),

gingival index (GI), and bleeding on probing (BOP), were recorded at baseline, 1 month, and 3 months.

Site-based analyses were performed by stratifying pockets into moderate (n=796) and deep (n=565).

Between-group comparisons were conducted using independent samples or Mann–Whitney U tests, and

within-group changes were analyzed using repeated measures ANOVA or Friedman test with Bonferroni

correction.

Results Both groups demonstrated significant improvements in all clinical parameters over time

(p<0.001). In full-mouth analyses, the HA group showed significantly lower GI and BOP values at 1 and 3

months, while PI values were comparable between groups. In moderate pockets, both groups exhibited

significant reductions in PD and CAL; however, the HA group demonstrated significantly lower values at

follow-up (p<0.001), with no additional change between 1 and 3 months. In deep pockets, PD reductions

were significant in both groups, while CAL improvements between 1 and 3 months were significant only

in the HA group (p<0.001).

Conclusions Non-surgical periodontal therapy resulted in significant clinical improvements. Adjunctive

HA application provided additional benefits, particularly in reducing inflammation and improving clinical

attachment, with more consistent effects observed in deep periodontal pockets.