Neuro-inflammation and anti-inflammatory treatment options for Alzheimer's disease

Ozben T., Ozben S.

CLINICAL BIOCHEMISTRY, vol.72, pp.87-89, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 72
  • Publication Date: 2019
  • Doi Number: 10.1016/j.clinbiochem.2019.04.001
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.87-89
  • Keywords: Inflammation, Alzheimer's disease, Treatment, NSAIDs, DEMENTIA, NSAIDS, AD
  • Akdeniz University Affiliated: Yes

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and dementia. The pathological characteristics of AD include the deposition of amyloid beta (A beta), neurofibrillary tangles, and neuronal loss. There is evidence showing the involvement of inflammation in AD, including activated microglia within and surrounding senile plaques. Epidemiological studies suggest the use of anti-inflammatory drugs to reduce incidence of AD. However, clinical trials with anti-inflammatory drugs have not been successful.