Effect of chronic stress and L-carnitine on rat stomach

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Izgut-Uysal V. N., Bulbul M., Tan R., Derin N., Ustunel I., Agar A., ...Daha Fazla

JOURNAL OF PHYSIOLOGICAL SCIENCES, cilt.57, sa.3, ss.187-192, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.2170/physiolsci.rp004707
  • Dergi Adı: JOURNAL OF PHYSIOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.187-192
  • Anahtar Kelimeler: restraint stress, L-carnitine, lipid peroxidation, gastric injury, REPEATED RESTRAINT STRESS, GASTRIC-MUCOSAL INJURY, RED-CELL LIPIDS, OXIDATIVE DAMAGE, SENSORY NERVES, AUTOXIDATION, PEROXIDATION, DERIVATIVES, PROTECTION, BRAIN
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background and Aim: L-Carnitine is an essential cofactor in the mitochondrial transfer of fatty acids, and it is also a scavenger of free radicals in mammalian tissues. The aim of the study was to determine the effect of L-carnitine on chronic restraint stress-induced gastric mucosal injury. Methods: Wistar rats were applied restraint stress (1 h/day) and L-carnitine (50 mg/kg) for 21 days. The lesion index, prostaglandin E-2 and mucus content, lipid peroxidation, superoxide dismutase, and catalase activity in gastric mucosa were evaluated. Results: Chronic restraint stress increased the lesion index, lipid peroxidation, and superoxide dismutase activity in gastric mucosa, and it decreased prostaglandin E2 and mucus content. L-Carnitine treatment prevented the stress-induced increase in lesion index, lipid peroxidation and a stress-induced decline in prostaglandin E-2, and mucus content in gastric mucosa, but it increased catalase activity. Conclusions: L-Carnitine prevents the occurrence of lesion by strengthening the gastric mucosal barrier and by reducing lipid peroxidation against the harmful effects of chronic restraint stress.