Is gastroesophageal reflux contribute to the development chronic cough by triggering pulmonary fibrosis

Aksu O., Songur N., Songür Y., ÖZTÜRK Ö., Adiloglu A. K., Kapucuoglu N., ...More

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.25, pp.48-53, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25
  • Publication Date: 2014
  • Doi Number: 10.5152/tjg.2014.4018
  • Journal Name: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.48-53
  • Keywords: Gastroesophageal reflux, chronic cough, pulmonary fibrozis, bronchoalveolar lavage, TNF-alpha, IL-1 beta, INTERLEUKIN-1 RECEPTOR ANTAGONIST, BRONCHOALVEOLAR LAVAGE, DISEASE, SCINTIGRAPHY, ESOPHAGITIS
  • Akdeniz University Affiliated: Yes

Abstract

Background/Aims: Previous studies have shown that the prevalence of abnormal acid reflux in fibrotic lung disease patients is high, and in particular, patients with secondary pulmonary fibrosis show higher esophageal acid exposure than normal controls. There are also some findings that, in patients with pathological reflux, pulmonary fibrosis may develop. The aim of this study is to investigate if pulmonary fibrosis is involved in the pathogenesis of chronic cough due to Gastroesophageal Reflux.