Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster
KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE, cilt.27, sa.2, ss.304-315, 2024 (ESCI)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 2
- Basım Tarihi: 2024
- Doi Numarası: 10.18016/ksutarimdoga.vi.1224968
- Dergi Adı: KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Agricultural & Environmental Science Database, CAB Abstracts, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.304-315
- Akdeniz Üniversitesi Adresli: Evet
Özet
The adverse effects of tetramethrin residues, a synthetic pyrethroid used
in many insecticide formulations, on environmental health and living
organisms are a matter of concern. The aim of this study was to evaluate
the genotoxic and developmental effects of tetramethrin in a non-target
organism, Drosophila melanogaster. Thus, its effect on DNA damage was
evaluated using the Comet assay in hemocytes, and its mutagenic and
recombinogenic effects were evaluated using Drosophila wing SMART.
Also, the effects of tetramethrin on Drosophila development were
evaluated by measuring larval weight, larval length, and fecundity.
Results showed that tetramethrin induced a decrease in the larval weight
and length only at a high concentration. Moreover, a decrease in
fecundity in a dose-dependent manner was observed. According to the
Comet assay results, DNA damage was not induced because there was no
significant increase in % DNA. However, tetramethrin caused
genotoxicity by inducing mitotic recombination in the SMART assay.