Investigation of Genotoxic and Development Effects of Tetramethrin on Drosophila melanogaster

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Atıf İçin Kopyala

Yalçın B., Güneş M., Tagorti G., Burgazlı A. Y., Golal E., Kaya B.

KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE, cilt.27, sa.2, ss.304-315, 2024 (ESCI)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 27 Sayı: 2
• Basım Tarihi: 2024
• Doi Numarası: 10.18016/ksutarimdoga.vi.1224968
• Dergi Adı: KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Agricultural & Environmental Science Database, CAB Abstracts, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.304-315
• Akdeniz Üniversitesi Adresli: Evet

Özet

The adverse effects of tetramethrin residues, a synthetic pyrethroid used in many insecticide formulations, on environmental health and living organisms are a matter of concern. The aim of this study was to evaluate the genotoxic and developmental effects of tetramethrin in a non-target organism, Drosophila melanogaster. Thus, its effect on DNA damage was evaluated using the Comet assay in hemocytes, and its mutagenic and recombinogenic effects were evaluated using Drosophila wing SMART. Also, the effects of tetramethrin on Drosophila development were evaluated by measuring larval weight, larval length, and fecundity. Results showed that tetramethrin induced a decrease in the larval weight and length only at a high concentration. Moreover, a decrease in fecundity in a dose-dependent manner was observed. According to the Comet assay results, DNA damage was not induced because there was no significant increase in % DNA. However, tetramethrin caused genotoxicity by inducing mitotic recombination in the SMART assay.