Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro

Basar M., Bozkurt I., Guzeloglu-Kayisli O., Sozen B., Tekmen I., Schatz F., ...More

FERTILITY AND STERILITY, vol.102, no.6, pp.1777-1784, 2014 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 102 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1016/j.fertnstert.2014.09.004
  • Journal Name: FERTILITY AND STERILITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1777-1784
  • Keywords: Preimplantation embryo development, endoplasmic reticulum stress, unfolded protein response, apoptosis, developmental arrest, ENDOPLASMIC-RETICULUM STRESS, ER STRESS, MITOCHONDRIAL PATHWAY, CELL-DEATH, APOPTOSIS, XBP-1, CHOP, ACTIVATION, INDUCTION, CASPASE
  • Akdeniz University Affiliated: Yes

Abstract

Objective: To study the effect of increased endoplasmic reticulum (ER) stress as a major nongenomic mechanism for arrested blastocyst development.