Extracellular ATP activates eNOS and increases intracellular NO generation in Red Blood Cells

ULKER P., ÖZEN N., ABDULLAYEVA G., KÖKSOY S., YARAŞ N., BASRALI F.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, vol.68, no.1, pp.89-101, 2018 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 68 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.3233/ch-170326
  • Journal Name: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.89-101
  • Keywords: Red blood cells, ATP, nitric oxide, purinergic receptors, NITRIC-OXIDE SYNTHASE, CULTURED ASTROCYTES, P2X(7) RECEPTOR, ERYTHROCYTES, MECHANISMS, CA2+, EXERCISE, RELEASE
  • Akdeniz University Affiliated: Yes

Abstract

BACKGROUND: It has been well documented that ATP activates NOS enzymes and causes increased NO production in several cell types. Although RBC known to possesses eNOS enzyme activity, it has not been investigated whether RBC eNOS could be induced by extracellular ATP.