Extracellular ATP activates eNOS and increases intracellular NO generation in Red Blood Cells

ULKER P., ÖZEN N., ABDULLAYEVA G., KÖKSOY S., YARAŞ N., BASRALI F.

CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, cilt.68, sa.1, ss.89-101, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.3233/ch-170326
  • Dergi Adı: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.89-101
  • Anahtar Kelimeler: Red blood cells, ATP, nitric oxide, purinergic receptors, NITRIC-OXIDE SYNTHASE, CULTURED ASTROCYTES, P2X(7) RECEPTOR, ERYTHROCYTES, MECHANISMS, CA2+, EXERCISE, RELEASE
  • Akdeniz Üniversitesi Adresli: Evet

Özet

BACKGROUND: It has been well documented that ATP activates NOS enzymes and causes increased NO production in several cell types. Although RBC known to possesses eNOS enzyme activity, it has not been investigated whether RBC eNOS could be induced by extracellular ATP.