Differential consequences of neurokinin receptor 1 and 2 antagonists in metastatic breast carcinoma cells; Effects independent of Substance P

NİZAM E., ERİN N.

BIOMEDICINE & PHARMACOTHERAPY, vol.108, pp.263-270, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 108
  • Publication Date: 2018
  • Doi Number: 10.1016/j.biopha.2018.09.013
  • Journal Name: BIOMEDICINE & PHARMACOTHERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.263-270
  • Keywords: Substance P, NK1 receptor, NK2 receptor, Breast cancer, Metastasis, MIP-2, CHEMOTHERAPY-INDUCED NAUSEA, NK-1 RECEPTOR, ANTITUMORAL ACTION, MITOGENIC ACTION, CANCER CELLS, NK1 RECEPTOR, INCREASED EXPRESSION, IN-VIVO, APREPITANT, LINES
  • Akdeniz University Affiliated: Yes

Abstract

Introduction: The biological action of Substance P (SP) is mediated mainly by NK-1 receptors (NK1R) followed by NK2 receptors (NK2R). Aberrant expression of NK1R and NK2R has been identified in various carcinomas. The role of Substance P and its receptors, especially NK2R in cancer progression is not entirely known and there are conflicting results in the literature demonstrating the need for further investigation. In the current study, we examined the effects of SP and antagonists selective for the NK1R and NK2R in breast carcinoma cells metastasize to vital organs.