Synthesis of novel ferrocenyl-containing pyrazolo[4,3-c]quinolines

TURGUT CİN G., Demirel S., Cakici A.

JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol.696, no.2, pp.613-621, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 696 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jorganchem.2010.10.006
  • Journal Name: JOURNAL OF ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.613-621
  • Keywords: Ferrocene, Pyrazolo[4,3-c]quinoline, Pyrazole, Quinoline, Pictet-Spengler reaction, Cyclization, PICTET-SPENGLER REACTION, BENZODIAZEPINE-RECEPTOR LIGANDS, ANTIMALARIAL ACTIVITY, ORGANOMETALLIC ANALOG, BIOLOGICAL EVALUATION, MODULATORS SERMS, IN-VITRO, X-RAY, RING, HETEROCYCLES
  • Akdeniz University Affiliated: Yes

Abstract

Synthesis of novel ferrocenyl-substituted pyrazolo[4,3-c]quinolines via the Pictet-Spengler reaction is reported. Iminium intermediate formed by the condensation of pyrazole-based arylamine substrates with ferrocenecarboxaldehyde in acidic medium, undergoes 6-endo cyclization with sufficiently reactive aromatic moiety to form a pyrazolo[4,3-c]quinoline ring. (c) 2010 Elsevier B.V. All rights reserved.