Inhibition of Rho-Kinase Improves Erectile Function, Increases Nitric Oxide Signaling and Decreases Penile Apoptosis in a Rat Model of Cavernous Nerve Injury

Hannan, Johanna; ALBERSEN, Maarten; Kutlu, ÖMER; GRATZKE, Christian; STIEF, Christian; Burnett, Arthur; Lysiak, Jeffrey; HEDLUND, Petter; Bivalacqua, Trinity

doi:10.1016/j.juro.2012.09.104

Inhibition of Rho-Kinase Improves Erectile Function, Increases Nitric Oxide Signaling and Decreases Penile Apoptosis in a Rat Model of Cavernous Nerve Injury

Hannan J. L., ALBERSEN M., Kutlu O., GRATZKE C., STIEF C. G., Burnett A. L., ...More

JOURNAL OF UROLOGY, vol.189, no.3, pp.1155-1161, 2013 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 189 Issue: 3
Publication Date: 2013
Doi Number: 10.1016/j.juro.2012.09.104
Journal Name: JOURNAL OF UROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1155-1161
Keywords: penis, apoptosis, prostatectomy, erectile dysfunction, rho-associated kinases, SMOOTH-MUSCLE, RADICAL PROSTATECTOMY, DYSFUNCTION, ACTIVATION, REGENERATION, MECHANISM, SYNTHASE, PATHWAY, CELLS, AKT
Open Archive Collection: AVESIS Open Access Collection
Akdeniz University Affiliated: No

Abstract

Purpose: Bilateral cavernous nerve injury results in up-regulation of ROCK signaling in the penis. This is linked to erectile dysfunction in an animal model of post-prostatectomy erectile dysfunction. We evaluated whether daily treatment with the ROCK inhibitor Y-27632 (Tocris Bioscience, Ellisville, Missouri) would prevent erectile dysfunction in a rat model of bilateral cavernous nerve injury.