Inhibition of Rho-Kinase Improves Erectile Function, Increases Nitric Oxide Signaling and Decreases Penile Apoptosis in a Rat Model of Cavernous Nerve Injury

Hannan, Johanna; ALBERSEN, Maarten; Kutlu, ÖMER; GRATZKE, Christian; STIEF, Christian; Burnett, Arthur; Lysiak, Jeffrey; HEDLUND, Petter; Bivalacqua, Trinity

doi:10.1016/j.juro.2012.09.104

Inhibition of Rho-Kinase Improves Erectile Function, Increases Nitric Oxide Signaling and Decreases Penile Apoptosis in a Rat Model of Cavernous Nerve Injury

Atıf İçin Kopyala

Hannan J. L., ALBERSEN M., Kutlu O., GRATZKE C., STIEF C. G., Burnett A. L., ...Daha Fazla

JOURNAL OF UROLOGY, cilt.189, sa.3, ss.1155-1161, 2013 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 189 Sayı: 3
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.juro.2012.09.104
Dergi Adı: JOURNAL OF UROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1155-1161
Anahtar Kelimeler: penis, apoptosis, prostatectomy, erectile dysfunction, rho-associated kinases, SMOOTH-MUSCLE, RADICAL PROSTATECTOMY, DYSFUNCTION, ACTIVATION, REGENERATION, MECHANISM, SYNTHASE, PATHWAY, CELLS, AKT
Akdeniz Üniversitesi Adresli: Hayır

Özet

Purpose: Bilateral cavernous nerve injury results in up-regulation of ROCK signaling in the penis. This is linked to erectile dysfunction in an animal model of post-prostatectomy erectile dysfunction. We evaluated whether daily treatment with the ROCK inhibitor Y-27632 (Tocris Bioscience, Ellisville, Missouri) would prevent erectile dysfunction in a rat model of bilateral cavernous nerve injury.