Inhibition of Rho-Kinase Improves Erectile Function, Increases Nitric Oxide Signaling and Decreases Penile Apoptosis in a Rat Model of Cavernous Nerve Injury

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Hannan J. L., ALBERSEN M., Kutlu O., GRATZKE C., STIEF C. G., Burnett A. L., ...Daha Fazla

JOURNAL OF UROLOGY, cilt.189, sa.3, ss.1155-1161, 2013 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 189 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.juro.2012.09.104
  • Dergi Adı: JOURNAL OF UROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1155-1161
  • Anahtar Kelimeler: penis, apoptosis, prostatectomy, erectile dysfunction, rho-associated kinases, SMOOTH-MUSCLE, RADICAL PROSTATECTOMY, DYSFUNCTION, ACTIVATION, REGENERATION, MECHANISM, SYNTHASE, PATHWAY, CELLS, AKT
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Akdeniz Üniversitesi Adresli: Hayır

Özet

Purpose: Bilateral cavernous nerve injury results in up-regulation of ROCK signaling in the penis. This is linked to erectile dysfunction in an animal model of post-prostatectomy erectile dysfunction. We evaluated whether daily treatment with the ROCK inhibitor Y-27632 (Tocris Bioscience, Ellisville, Missouri) would prevent erectile dysfunction in a rat model of bilateral cavernous nerve injury.