The Cutoff Level for Urine Protein in Urine Immunofixation Electrophoresis

Ellidag H. Y., Curek G., Eren E., Aydin O., Yilmaz N.

CLINICAL LABORATORY, vol.61, no.10, pp.1525-1530, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.7754/clin.lab.2015.150230
  • Journal Name: CLINICAL LABORATORY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1525-1530
  • Keywords: electrophoresis, monoclonal gammopathy, multiple myeloma, Bence Jones proteinuria, urine protein, urine albumin, MONOCLONAL LIGHT-CHAINS
  • Akdeniz University Affiliated: Yes

Abstract

Background: Immunofixation electrophoresis (IFE) maintains its importance in diagnosing monoclonal gammopathies. In particular, urine IFE detects free light chains (FLC) in urine samples even at low concentrations and offers higher sensitivity compared to serum electrophoresis and serum IFE. The aim of the present study was to determine the place and significance of quantitative urinary protein measurement before IFE in interpreting the results of subsequent IFE and to determine the most appropriate protein concentrations for the appearance of bands.