Angiogenesis in neurological disorders: a review

Acar G., TANRIÖVER G., Demir R.

NEUROLOGICAL RESEARCH, vol.34, no.7, pp.627-635, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 34 Issue: 7
  • Publication Date: 2012
  • Doi Number: 10.1179/1743132812y.0000000068
  • Journal Name: NEUROLOGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.627-635
  • Keywords: Angiogenesis, Anti-angiogenic therapies, Neurological disorders, Tumor metastasis, ENDOTHELIAL-GROWTH-FACTOR, BRAIN ARTERIOVENOUS-MALFORMATIONS, RECEPTOR TYROSINE KINASES, CENTRAL-NERVOUS-SYSTEM, HUMAN CEREBROVASCULAR MALFORMATIONS, RECURRENT MALIGNANT GLIOMAS, GENE MICROARRAY ANALYSIS, MULTICENTER PHASE-II, EARLY HUMAN PLACENTA, IN-VIVO
  • Akdeniz University Affiliated: Yes

Abstract

Angiogenesis, recruitment of new blood vessels, is an essential component of the metastatic pathway. These vessels provide the principal route by which tumor cells exit the primary tumor site and enter the circulation. For many tumors, the vascular density can provide a prognostic indicator of metastatic potential, with the highly vascular primary tumors having a higher incidence of metastasis than poorly vascular tumors. The discovery and characterization of tumor-derived angiogenesis modulators greatly contributed to our understanding of how tumors regulate angiogenesis. However, although angiogenesis appears to be a rate-limiting event in tumor growth and metastatic dissemination, a direct connection between the induction of angiogenesis and the progression to tumor malignancy is less well understood. In this review, we discuss the observations concerning the modulation of angiogenesis and their implications in various neurological disorders, as well as their potential impact on cancer therapy.