The association between endothelial dysfunction and hypertensive retinopathy in essential hypertension

Creative Commons License

Karaca M., ÇOBAN E., ÖZDEM S., ÜNAL M., SALİM O., OrhanYucel O.

MEDICAL SCIENCE MONITOR, cilt.20, ss.78-82, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20
  • Basım Tarihi: 2014
  • Doi Numarası: 10.12659/msm.889659
  • Dergi Adı: MEDICAL SCIENCE MONITOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.78-82
  • Anahtar Kelimeler: von Willebrand factor, endothelial dysfunction, hypertensive retinopathy, VON-WILLEBRAND-FACTOR, MEAN PLATELET VOLUME, TARGET ORGAN DAMAGE, MARKER
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: Endothelial dysfunction, which is characterized by an imbalance between relaxing and contracting factors, procoagulant and anticoagulant substances, and between pro-inflammatory mediators, may play a particularly significant role in the pathogenesis of atherosclerosis. Numerous experimental and clinical reports suggest that a high von Willebrand factor (vWF) level reflects endothelial damage or dysfunction. Hypertensive retinopathy (HR) is a condition characterized by a spectrum of retinal vascular signs in people with elevated blood pressure. The pathophysiological mechanism of HR is not completely understood. Elevated blood pressure alone does not fully account for the extent of retinopathy. Endothelial dysfunction and mechanisms known to be involved in vascular lesions may be involved in the pathophysiological mechanism of HR. Therefore, this study was designed to answer the following questions: (i) Do vWf levels change in HR? and (ii) Is there any relation between degree of HR and vWf levels?