Urinary 8-isoprostane levels can indicate the presence, severity and extent of angiographic coronary artery disease
ACTA CARDIOLOGICA, vol.63, no.4, pp.415-422, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 63 Issue: 4
- Publication Date: 2008
- Doi Number: 10.2143/ac.63.4.2033038
- Journal Name: ACTA CARDIOLOGICA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.415-422
- Keywords: oxidative stress, isoprostone, atherosclerosis, coronary artery disease, Gensini score, C-REACTIVE PROTEIN, OXIDATIVE STRESS, HEART-DISEASE, 8-ISO-PROSTAGLANDIN F2-ALPHA, PLASMA F-2-ISOPROSTANES, CARDIOVASCULAR-DISEASE, DENSITY-LIPOPROTEIN, LIPID-PEROXIDATION, VULNERABLE PATIENT, RISK-ASSESSMENT
- Akdeniz University Affiliated: Yes
Abstract
Background-Atherosclerotic coronary artery disease is the leading cause of death worldwide. Oxidative stress is one of the key elements in the pathogenesis of atherosclerosis. Isoprostanes are established markers of oxidative stress. The aim of this study was to investigate the association of urinary 8-isoprostane levels with the presence and severity of coronary artery disease (CAD) assessed by a validated scoring system.