Prothrombin complex concentrates utility for warfarin-associated hemorrhage

SÖYÜNCÜ S., ASLAN S., MUTLU H., Bektas F.

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, cilt.8, sa.2, ss.2778-2783, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 2
  • Basım Tarihi: 2015
  • Dergi Adı: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2778-2783
  • Anahtar Kelimeler: Prothrombin complex concentrate, warfarin, hemorrhage, FRESH-FROZEN PLASMA, ORAL ANTICOAGULANT REVERSAL, VITAMIN-K ANTAGONISTS, FACTOR-IX COMPLEX, AUSTRALASIAN-SOCIETY, CONSENSUS GUIDELINES, THROMBOSIS, THERAPY, COAGULOPATHY, EFFICACY
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Introduction: Prothrombin Complex Concentrate (PCC) for reversal of warfarin is the main therapeutic option in cases of life-threatening bleeding. Aim of the study was to investigate for using 4-factor PCC brought to the therapeutic levels of International Normalized Ratio (INR) values in cases of life-threatening bleeding in Emergency Department. Methods: This retrospective cohort study was performed in a tertiary care university emergency department. Patients with active bleeding who were taking warfarin with INR levels of >= 1.5, and had received 4-factor prothrombin complex concentrate for treatment were included in to study. Results: A total of 75 patients were included in the study. The median age of the study participants was 68 (minimum 23 to maximum 87) years and 45.3% (n = 34) of them were male. INR levels was normalized all patients who were received 4-factor PCC. Red blood cell (RBC) was transfused in 16 patients (21%) because of the low hemoglobin levels. Mean unite of the RBC packet was 2,75. The lengths of hospital stay of receiving 4-factor PCC rate were determined 4.9 +/- 8.7 days. No thrombotic complications or adverse drug reactions were observed after 4-factor PCC administration in any of the patients. Conclusions: In our study 4-factor PCC was found to be effective and safe in rapidly reversing the effects of warfarin.