Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells

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Yuzugullu H., Benhaj K., Ozturk N., ŞENTÜRK Ş., Celik E., TOYLU A., ...More

MOLECULAR CANCER, vol.8, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 8
  • Publication Date: 2009
  • Doi Number: 10.1186/1476-4598-8-90
  • Journal Name: MOLECULAR CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Akdeniz University Affiliated: Yes

Abstract

Background: beta-catenin mutations that constitutively activate the canonical Wnt signaling have been observed in a subset of hepatocellular carcinomas (HCCs). These mutations are associated with chromosomal stability, low histological grade, low tumor invasion and better patient survival. We hypothesized that canonical Wnt signaling is selectively activated in well-differentiated, but repressed in poorly differentiated HCCs. To this aim, we characterized differentiation status of HCC cell lines and compared their expression status of Wnt pathway genes, and explored their activity of canonical Wnt signaling.