Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells

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Yuzugullu H., Benhaj K., Ozturk N., ŞENTÜRK Ş., Celik E., TOYLU A., ...Daha Fazla

MOLECULAR CANCER, cilt.8, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1186/1476-4598-8-90
  • Dergi Adı: MOLECULAR CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background: beta-catenin mutations that constitutively activate the canonical Wnt signaling have been observed in a subset of hepatocellular carcinomas (HCCs). These mutations are associated with chromosomal stability, low histological grade, low tumor invasion and better patient survival. We hypothesized that canonical Wnt signaling is selectively activated in well-differentiated, but repressed in poorly differentiated HCCs. To this aim, we characterized differentiation status of HCC cell lines and compared their expression status of Wnt pathway genes, and explored their activity of canonical Wnt signaling.