Immunophilin ligands in peripheral nerve regeneration

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Kandemir Y. B., SARIKCIOĞLU L.

FOLIA MORPHOLOGICA, cilt.74, sa.4, ss.407-413, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 74 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.5603/fm.2015.0100
  • Dergi Adı: FOLIA MORPHOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.407-413
  • Anahtar Kelimeler: immunophilins, FK506, cyclosporin A, rapamycin, peripheral nerve, RAT SCIATIC-NERVE, IMMUNOSUPPRESSANT FK506 INCREASES, FOCAL CEREBRAL-ISCHEMIA, THERAPEUTIC TIME WINDOW, SPINAL-CORD-INJURY, CYCLOSPORINE-A, TACROLIMUS FK506, NEUROIMMUNOPHILIN LIGANDS, SACCHAROMYCES-CEREVISIAE, AXONAL REGENERATION
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Immunophilins are a family of receptors for immunosuppressive drugs like cyclosporin A, FK506, rapamycin and their non-immunosuppressive analogues, which are collectively referred to as immunophilin ligands. The present study aimed to review neuroprotective and neuroregenerative actions of immunophilin ligands on peripheral nerve injuries. The special emphasis was given to well-known immunosuppressive drug FK506. Its historical background, administration routes, dosages, neuroregenerative, neuroprotective actions, therapeutic time window in administration, action mechanism and side effects of FK506 were reviewed.