Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Gastric Ischemia-Reperfusion: Role of Angiotensin II

Gemici B., Tan R., ÖNGÜT G., Izgut-Uysal V. N.

JOURNAL OF SURGICAL RESEARCH, vol.161, no.1, pp.126-133, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 161 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.1016/j.jss.2009.07.018
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.126-133
  • Keywords: angiotensin II, ischemia-reperfusion, iNOS, COX-2, candesartan, PD123319, captopril, FACTOR-KAPPA-B, MUCOSAL INJURY, L-CARNITINE, RECEPTOR, AT(1), PROSTAGLANDIN, INFLAMMATION, ACTIVATION, INHIBITION, PROTECTS
  • Akdeniz University Affiliated: Yes

Abstract

Background. Angiotensin II contributes to the pathogenesis of inflammation induced by ischemia-reperfusion (I/R) in various organs. Angiotensin II increases vascular permeability that initiates the inflammatory process and leads to the migration of inflammatory cells into the tissue. The aim of the present study was to investigate the effect of angiotensin II on ischemia-reperfusion induced expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in rat stomachs exposed to ischemia-reperfusion.