Expressions of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Gastric Ischemia-Reperfusion: Role of Angiotensin II

Gemici B., Tan R., ÖNGÜT G., Izgut-Uysal V. N.

JOURNAL OF SURGICAL RESEARCH, cilt.161, sa.1, ss.126-133, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 161 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jss.2009.07.018
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.126-133
  • Anahtar Kelimeler: angiotensin II, ischemia-reperfusion, iNOS, COX-2, candesartan, PD123319, captopril, FACTOR-KAPPA-B, MUCOSAL INJURY, L-CARNITINE, RECEPTOR, AT(1), PROSTAGLANDIN, INFLAMMATION, ACTIVATION, INHIBITION, PROTECTS
  • Akdeniz Üniversitesi Adresli: Evet

Özet

Background. Angiotensin II contributes to the pathogenesis of inflammation induced by ischemia-reperfusion (I/R) in various organs. Angiotensin II increases vascular permeability that initiates the inflammatory process and leads to the migration of inflammatory cells into the tissue. The aim of the present study was to investigate the effect of angiotensin II on ischemia-reperfusion induced expressions of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in rat stomachs exposed to ischemia-reperfusion.