HMGB1 expression in urothelial carcinoma of the bladder

Suren D., Yildirim H. T., Atalay I., Sayiner A., Yildirim M., Alikanoglu A. S., ...More

JOURNAL OF BUON, vol.23, no.6, pp.1882-1886, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2018
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1882-1886
  • Keywords: bladder neoplasms, diagnostic use, HMGB1 protein, pathology, prognosis, BACILLUS-CALMETTE-GUERIN, GROUP BOX 1, SQUAMOUS-CELL CARCINOMA, MOBILITY GROUP BOX-1, POOR-PROGNOSIS, CANCER CELLS, PROGRESSION, INTERFERON-ALPHA-2B, OVEREXPRESSION, PROTEINS
  • Akdeniz University Affiliated: Yes

Abstract

Purpose: HMGB1, the most important member of the high mobility group box protein family, is a nuclear protein with different functions in the cell; it has a role in cancer progression, angiogenesis, invasion, and metastasis development. We studied the expression of HMGB1 and whether it is a prognostic factor in urothelial carcinoma of bladder (UCB) or not.