Effect of exercise intensity on cerebrospinal fluid interleukin-6 concentration during recovery from exhaustive exercise in rats

KILIÇ M. A., Ulusoy O., Cirrik S., HİNDİSTAN İ. E., ÖZKAYA Y. G.

ACTA PHYSIOLOGICA HUNGARICA, cilt.101, sa.1, ss.21-31, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 101 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1556/aphysiol.100.2013.019
  • Dergi Adı: ACTA PHYSIOLOGICA HUNGARICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.21-31
  • Anahtar Kelimeler: strenuous training, cerebrospinal fluid, swimming, exhaustion, glycogen supercompensation, interleukin-6, cytokines, HUMAN SKELETAL-MUSCLE, AUTOCRINE REGULATION, FOOD RESTRICTION, INDUCED INCREASE, ADIPOSE-TISSUE, HUMANS, BRAIN, EXPRESSION, SECRETION, CYTOKINES
  • Akdeniz Üniversitesi Adresli: Evet

Özet

The purpose of this study was to investigate the possible role of moderate and strenuous swimming training on plasma and cerebrospinal fluid (CSF) IL-6 (interleukin-6) levels during recovery from exhaustive exercise in rats. Wistar rats were divided into three groups: sedentary control (C), moderately trained (MT) and strenuously trained (ST). MT rats underwent swimming exercise for one hour/day and 5 days/week for 8 weeks. Animals in the ST group began swimming with 1 h/day and swimming duration was progressively increased by 30 min/wk, reaching 2.5 h/day by week 4 and stayed constant for an additional 4 weeks. After all animals underwent an acute exhaustive swimming exercise, animals were divided into 3 groups, and decapitated immediately, 24 and 48 hours after exhaustion to obtain tissue samples. Muscle citrate synthase activity, plasma and CSF IL-6 levels were determined. The citrate synthase activity was found to be higher in MT and ST groups compared to the C group. Although plasma IL-6 levels were found unaltered among all groups, the CSF IL-6 concentration was found to be increased 24 hours after exhaustive exercise of the ST group. We conclude that exercise training intensity is an important factor determining cerebrospinal IL-6 concentration after exhaustive exercise.