Lack of any Prognostic Role of Insulin-Like Growth Factor-1 Receptor in Non- Small Cell Lung Cancer

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Dilli U. D., Yildirim M., Suren D., Alikanoglu A., KAYA V., Goktas S., ...More

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol.15, no.14, pp.5753-5757, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 14
  • Publication Date: 2014
  • Doi Number: 10.7314/apjcp.2014.15.14.5753
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5753-5757
  • Keywords: IGF1R, insulin, like growth factor, 1 receptor, lung cancer, prognosis, CLINICAL-SIGNIFICANCE, EXPRESSION, IGF, COMBINATION, RESISTANCE, MUTATIONS, PATHOLOGY, SURVIVAL, RISK, AXIS
  • Akdeniz University Affiliated: Yes


Background: The purpose of this study is to determine whether the IGF1R expression has a prognostic role in non-small cell lung cancer. Materials and Methods: Forty-seven patients histopathologically diagnosed with small cell lung cancer upon bronchoscopic biopsy or resection materials were included in the study. IGF1R expression was examined via immunohistochemical methods. In samples, > 10% staining were assessed as positive and <= 10% as negative. Information about demographic datas and treatments was obtained by retrospective searches of patient files. Results: IGF1R expression was determined as positive in 38 (80.9%) and as negative in 9 (19.1%) patients. There was no significant relation between IGF1R expression and histological sub-type, local invasion, lymph node and metastasis status (p=0.842, p=0.437, 0.064, 0.447, respectively). There was also no correlation with IGF1R expression and survival (p=0.141). Conclusions: There are conflicting results between IGF1R and its prognostic effects in the various studies. It has been claimed in some studies it is not related to prognosis as in our study, and in some studies it has been claimed that it is a good prognostic factor whereas in some studies it has been claimed as being a factor for worse prognosis. We think that IGF1R expression in non-small cell lung carcinoma patients deserves further analysis, because of its potential prognostic and predictive roles.