The effect of pentoxifylline on haemolysis during cardiopulmonary bypass in open-heart surgery

Gölbaşı İ., Akbas H., Ozdem S., Ukan S., Ozdem S., Kabukcu H., ...More

ACTA CARDIOLOGICA, vol.61, no.1, pp.7-11, 2006 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 61 Issue: 1
  • Publication Date: 2006
  • Doi Number: 10.2143/ac.61.1.2005134
  • Journal Name: ACTA CARDIOLOGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.7-11
  • Keywords: pentoxifylline, haemolysis, cardiopulmonary bypass, haemoglobin, haptoglobin, INTERNAL THORACIC ARTERY, RED-CELL DEFORMABILITY, FREE HEMOGLOBIN, INFLAMMATORY RESPONSE, ISCHEMIA-REPERFUSION, LUNG, INHIBITION, ACTIVATION, INJURY
  • Akdeniz University Affiliated: Yes

Abstract

Objective - Haemolysis has long been recognized as one of the responses to cardiopulmonary bypass (CPB). Pentoxifylline (PTX), a methylxanthine derivative, has been known for many years for its haemorrheological properties. In this prospective, randomized study, we investigated whether a PTX treatment would reduce the haemolysis during CPB.