Veno-occlusive disease-like hepatotoxicity in two children receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney

Hazar V., Kutluk T., Akyuz C., Varan A., Yaris N., Buyukpamukcu M.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.15, no.1, pp.85-89, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 1998
  • Doi Number: 10.3109/08880019809009513
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.85-89
  • Keywords: clear cell sarcoma of kidney, hepatotoxicity, veno-occlusive disease, Wilms' tumor, LIVER, VINCRISTINE
  • Akdeniz University Affiliated: No


We report two pediatric cases who developed veno-occlusive disease-like hepatotoxicity while receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney. The chemotherapeutics, including-vincristine, actinomycin D, and epirubicin in case I and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed. Other possible causes of hepatotoxicity were excluded. Recovery was observed with supportive therapy after 2 and 1 weeks, respectively. After recovery, the children tolerated continued chemotherapy without any decrease in the doses of drugs. We conclude that vincristine and actinomycin D were the cause of this rare form of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.