Veno-occlusive disease-like hepatotoxicity in two children receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney
PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.15, no.1, pp.85-89, 1998 (SCI-Expanded)
- Publication Type: Article / Article
- Volume: 15 Issue: 1
- Publication Date: 1998
- Doi Number: 10.3109/08880019809009513
- Journal Name: PEDIATRIC HEMATOLOGY AND ONCOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.85-89
- Keywords: clear cell sarcoma of kidney, hepatotoxicity, veno-occlusive disease, Wilms' tumor, LIVER, VINCRISTINE
- Akdeniz University Affiliated: No
Abstract
We report two pediatric cases who developed veno-occlusive disease-like hepatotoxicity while receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney. The chemotherapeutics, including-vincristine, actinomycin D, and epirubicin in case I and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed. Other possible causes of hepatotoxicity were excluded. Recovery was observed with supportive therapy after 2 and 1 weeks, respectively. After recovery, the children tolerated continued chemotherapy without any decrease in the doses of drugs. We conclude that vincristine and actinomycin D were the cause of this rare form of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.