Veno-occlusive disease-like hepatotoxicity in two children receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney
PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.15, sa.1, ss.85-89, 1998 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 1
- Basım Tarihi: 1998
- Doi Numarası: 10.3109/08880019809009513
- Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.85-89
- Anahtar Kelimeler: clear cell sarcoma of kidney, hepatotoxicity, veno-occlusive disease, Wilms' tumor, LIVER, VINCRISTINE
- Akdeniz Üniversitesi Adresli: Hayır
Özet
We report two pediatric cases who developed veno-occlusive disease-like hepatotoxicity while receiving chemotherapy for Wilms' tumor and clear cell sarcoma of kidney. The chemotherapeutics, including-vincristine, actinomycin D, and epirubicin in case I and vincristine and actinomycin D in case 2, were given before the hepatotoxicity developed. Other possible causes of hepatotoxicity were excluded. Recovery was observed with supportive therapy after 2 and 1 weeks, respectively. After recovery, the children tolerated continued chemotherapy without any decrease in the doses of drugs. We conclude that vincristine and actinomycin D were the cause of this rare form of hepatotoxicity and that chemotherapy for the underlying malignant disease could be given safely after clinical recovery.