The close relationship between oocyte aging and telomere shortening, and possible interventions for telomere protection

ÖZTÜRK S.

Mechanisms of Ageing and Development, cilt.218, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 218
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.mad.2024.111913
  • Dergi Adı: Mechanisms of Ageing and Development
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Abstracts in Social Gerontology, BIOSIS, Business Source Elite, Business Source Premier, CAB Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Female infertility, Follicles, Oocyte aging, Telomere shortening, Therapeutic interventions
  • Akdeniz Üniversitesi Adresli: Evet

Özet

As women delay childbearing due to socioeconomic reasons, understanding molecular mechanisms decreasing oocyte quantity and quality during ovarian aging becomes increasingly important. The ovary undergoes biological aging at a higher pace when compared to other organs. As is known, telomeres play crucial roles in maintaining genomic integrity, and their shortening owing to increased reactive oxygen species, consecutive cellular divisions, genetic and epigenetic alterations is associated with loss of developmental competence of oocytes. Novel interventions such as antioxidant treatments and regulation of gene expression are being investigated to prevent or rescue telomere attrition and thereby oocyte aging. Herein, potential factors and molecular mechanisms causing telomere shortening in aging oocytes were comprehensively reviewed. For the purpose of extending reproductive lifespan, possible therapeutic interventions to protect telomere length were also discussed.